The PROMINENT team is supported through the Cancer Grand Challenges initiative. Learn more here

Publications

2024

  1. Sánchez-Guixé M, Muiños F, Pinheiro-Santin M, González-Huici V, Rodriguez-Hernandez CJ, Avgustinova A, Lavarino C, González-Pérez A, Mora J, López-Bigas N. Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues. Cancer Discov. 2024 Jun 3;14(6):953-964. doi: 10.1158/2159-8290.CD-23-1186. PMID: 38501975; PMCID: PMC11145171.

2. Taylor MA, Kandyba E, Halliwill K, Delrosario R, Khoroshkin M, Goodarzi H, Quigley D, Li YR, Wu D, Bollam SR, Mirzoeva OK, Akhurst RJ, Balmain A. Stem-cell states converge in multistage cutaneous squamous cell carcinoma development. Science. 2024 May 31;384(6699):eadi7453. doi: 10.1126/science.adi7453. Epub 2024 May 31. PMID: 38815020.

3. Demajo S, Ramis-Zaldivar JE, Muinos F, Grau ML, Andrianova M, Lopez-Bigas N, Gonzalez-Perez A. Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis. Cancer Discov. 2024 May 9. doi: 10.1158/2159-8290.CD-23-1416. Epub ahead of print. PMID: 38722595.

4. Swanton C, Bernard E, Abbosh C, André F, Auwerx J, Balmain A, Bar-Sagi D, Bernards R, Bullman S, DeGregori J, Elliott C, Erez A, Evan G, Febbraio MA, Hidalgo A, Jamal-Hanjani M, Joyce JA, Kaiser M, Lamia K, Locasale JW, Loi S, Malanchi I, Merad M, Musgrave K, Patel KJ, Quezada S, Wargo JA, Weeraratna A, White E, Winkler F, Wood JN, Vousden KH, Hanahan D. Embracing cancer complexity: Hallmarks of systemic disease. Cell. 2024 Mar 28;187(7):1589-1616. doi: 10.1016/j.cell.2024.02.009. PMID: 38552609.

5. Arnedo-Pac C, Muiños F, Gonzalez-Perez A, Lopez-Bigas N. Hotspot propensity across mutational processes. Mol Syst Biol. 2024 Jan;20(1):6-27. doi: 10.1038/s44320-023-00001-w. Epub 2023 Dec 20. PMID: 38177930.

6. Groarke JD, Crawford J, Collins SM, Lubaczewski S, Roeland EJ, Naito T, Hendifar AE, Fallon M, Takayama K, Asmis T, Dunne RF, Karahanoglu I, Northcott CA, Harrington MA, Rossulek M, Qiu R, Saxena AR. Ponsegromab for the Treatment of Cancer Cachexia. N Engl J Med. 2024 Sep 14. doi: 10.1056/NEJMoa2409515. Epub ahead of print. PMID: 39282907.

2023

  1. Reeves MQ, Balmain A. Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression. Cold Spring Harb Perspect Med. 2023 Dec 5:a041388. doi: 10.1101/cshperspect.a041388. Online ahead of print. PMID: 38052482

2022

  1. Balmain A. Peto’s paradox revisited: black box vs mechanistic approaches to understanding the roles of mutations and promoting factors in cancer. Eur J Epidemiol. 2022 Dec 13. doi: 10.1007/s10654-022-00933-x. Online ahead of print. PMID: 36512199

Other relevant PROMINENT team publications

  1. PROMINENT work cited in The New Yorker magazine. Siddhartha Mukherjee. All the Carcinogens We Cannot See. The New Yorker. December 11, 2023

2. Senkin S, Moody S, Díaz-Gay M, Abedi-Ardekani B, Cattiaux T, Ferreiro-Iglesias A, Wang J, Fitzgerald S, Kazachkova M, Vangara R, Le AP, Bergstrom EN, Khandekar A, Otlu B, Cheema S, Latimer C, Thomas E, Atkins JR, Smith-Byrne K, Cortez Cardoso Penha R, Carreira C, Chopard P, Gaborieau V, Keski-Rahkonen P, Jones D, Teague JW, Ferlicot S, Asgari M, Sangkhathat S, Attawettayanon W, Świątkowska B, Jarmalaite S, Sabaliauskaite R, Shibata T, Fukagawa A, Mates D, Jinga V, Rascu S, Mijuskovic M, Savic S, Milosavljevic S, Bartlett JMS, Albert M, Phouthavongsy L, Ashton-Prolla P, Botton MR, Silva Neto B, Bezerra SM, Curado MP, Zequi SC, Reis RM, Faria EF, de Menezes NS, Ferrari RS, Banks RE, Vasudev NS, Zaridze D, Mukeriya A, Shangina O, Matveev V, Foretova L, Navratilova M, Holcatova I, Hornakova A, Janout V, Purdue MP, Rothman N, Chanock SJ, Ueland PM, Johansson M, McKay J, Scelo G, Chanudet E, Humphreys L, de Carvalho AC, Perdomo S, Alexandrov LB, Stratton MR, Brennan P. Geographic variation of mutagenic exposures in kidney cancer genomes. 2024 May;629(8013):910-918. doi: 10.1038/s41586-024-07368-2. Epub 2024 May 1. PMID: 38693263; PMCID: PMC11111402.

3. Perdomo S, Abedi-Ardekani B, de Carvalho AC, Ferreiro-Iglesias A, Gaborieau V, Cattiaux T, Renard H, Chopard P, Carreira C, Spanu A, Nikmanesh A, Cardoso Penha RC, Antwi SO, Ashton-Prolla P, Canova C, Chitapanarux T, Cox R, Curado MP, de Oliveira JC, Dzamalala C, Fabianova E, Ferri L, Fitzgerald R, Foretova L, Gallinger S, Goldstein AM, Holcatova I, Huertas A, Janout V, Jarmalaite S, Kaneva R, Kowalski LP, Kulis T, Lagiou P, Lissowska J, Malekzadeh R, Mates D, McCorrmack V, Menya D, Mhatre S, Mmbaga BT, de Moricz A, Nyirády P, Ognjanovic M, Papadopoulou K, Polesel J, Purdue MP, Rascu S, Rebolho Batista LM, Reis RM, Ribeiro Pinto LF, Rodríguez-Urrego PA, Sangkhathat S, Sangrajrang S, Shibata T, Stakhovsky E, Świątkowska B, Vaccaro C, Vasconcelos de Podesta JR, Vasudev NS, Vilensky M, Yeung J, Zaridze D, Zendehdel K, Scelo G, Chanudet E, Wang J, Fitzgerald S, Latimer C, Moody S, Humphreys L, Alexandrov LB, Stratton MR, Brennan P. The Mutographs biorepository: A unique genomic resource to study cancer around the world. Cell Genom. 2024 Mar 13;4(3):100500. doi: 10.1016/j.xgen.2024.100500. Epub 2024 Feb 6. PMID: 38325367; PMCID: PMC10943582.

4. Polak R, Zhang ET, Kuo CJ. Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment. Nat Rev Cancer. 2024 Jul 8. doi: 10.1038/s41568-024-00706-6. Epub ahead of print. PMID: 38977835.

5. Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Casals AM, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Muller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ. Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging. Nat Methods. 2023 Aug;20(8):1174-1178. doi: 10.1038/s41592-023-01846-7. Epub 2023 Jul 19. PMID: 37468619; PMCID: PMC10406602.

6. Balmain A. Air pollution’s role in the promotion of lung cancer. Nature. 2023 Apr;616(7955):35-36. doi: 10.1038/d41586-023-00929-x. PMID: 37020001.

7. Davey Smith G, Hofman A, Brennan P. Chance, ignorance, and the paradoxes of cancer: Richard Peto on developing preventative strategies under uncertainty. Eur J Epidemiol. 2023 Dec;38(12):1227-1237. doi: 10.1007/s10654-023-01090-5. Epub 2023 Dec 26. PMID: 38147198.

CGC
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